U-M researchers: Canker sore drug could be used for weight loss
Editor's note: The photo credit has been corrected.
The next weight-loss drug could be one already familiar to those with asthma and canker sores, according to researchers at the University of Michigan.
Obese mice treated with the drug Amlexanox lost weight and reversed metabolic problems such as diabetes and fatty livers.
Courtesy of the U-M Life Sciences Institute
Research conducted by Dr. Alan Saltiel, director of the Life Sciences Institute at U-M, found the drug inhibits two genes that play a role in metabolism and fat-burning in mice.
Dr. Elif Oral, associate professor of internal medicine and medical director of U-M Health System's Bariatric Surgery Program, is seeking individuals who are obese or have Type 2 diabetes for a new study to test the drug's effects on humans.
Individuals can be on oral diabetes medication and should have a body mass index between 27 and 36. Only 10 people are needed for this stage of the clinical trial.
Amy Biolchini covers Washtenaw County, health and environmental issues for AnnArbor.com. Reach her at (734) 623-2552, amybiolchini@annarbor.com or on Twitter.
Comments
An Arborigine
Tue, Jul 2, 2013 : 1:05 p.m.
Four out of five mice in the study group reported increased self-esteem and and noted more "admiring glances" from other rodents.
Mike
Tue, Jul 2, 2013 : 12:12 a.m.
Animal abuse.
Technojunkie
Tue, Jul 2, 2013 : 12:08 a.m.
You could try eliminating inflammatory foods like grains, soy, seed oils and refined sugar in favor of healthy fats, pastured meats and eggs, and organic veggies. That won't sell drugs nor industrial food-like products though.
E Claire
Tue, Jul 2, 2013 : 3:12 p.m.
Love how you get voted down for suggesting people actually take some responsibility.
TryingToBeObjective
Mon, Jul 1, 2013 : 11:14 p.m.
Individuals who volunteer also have to have advanced liver disease and may have to have liver biopsies. Just a few significant details.....
obviouscomment
Mon, Jul 1, 2013 : 9:52 p.m.
I didn't even know there were drugs for canker sores...I get them all the time and I thought it was just something I have to live with...interesting...
Brad
Tue, Jul 2, 2013 : 11:38 p.m.
Put alum on the canker sore. Keep it there as long as you can stand the pain, and then take some water and wash your mouth with it. Don't swallow it. You canker sore will be gone the next day.
justcurious
Tue, Jul 2, 2013 : 6:50 p.m.
LAEL after almost a lifetime of mouth pain I discovered my allergy to Sodium Lauryl Sulfate was the problem. I now use toothpastes that don't contain it. It is also used in other body products and is listed on the labels.
LAEL
Tue, Jul 2, 2013 : 1:23 p.m.
Before trying a drug, try using a toothpaste that does not have any SLS (Sodium Lauryl Sulfate) in it and see if that doesn't help clear up your canker sores after a few weeks. Sensodyne has some good sls-free versions. (Many major brands these days have an sls-free toothpaste.)
Ann English
Mon, Jul 1, 2013 : 11:17 p.m.
You could ask your dentist for some other canker sore drugs than amlexonox; I never heard of this drug from the UM Dental School, but of some over-the-counter ones. I imagine you have told your doctor you get them; when I first got one, a doctor I had at that time diagnosed it, but didn't tell me of any canker sore drugs. Just saltwater rinsing.